Hematopoietic stem cells are a long-term reservoir for trained immunity in a mouse model of chronic autoimmune disease
T. S. Mills, B. Kain, M. T. Burchill, E. Danis, A. Goodspeed, R. Culp-Hill, S. Ferrara, J. R. Roede, A. D'Alessandro, K. Y. King, E. M. Pietras
The paper shows hematopoietic stem cells (HSCs) in a mouse model of chronic autoimmune disease serve as a long-term reservoir for trained immunity, with macrophages derived from them exhibiting increased inflammatory activity and reduced metabolic function.
bioRxiv · May 20, 2022 · PreprintImmunology