The early evolution of oral poliovirus vaccine is shaped by strong positive selection and tight transmission bottlenecks
A. L. Valesano, M. Taniuchi, W. J. Fitzsimmons, M. O. Islam, T. Ahmed, K. Zaman, R. Haque, W. Wong, M. Famulare, A. S. Lauring
This study uses high-depth genome sequencing to analyze the early evolution of monovalent OPV2 in vaccinated individuals and their contacts, revealing strong positive selection and tight transmission bottlenecks.
bioRxiv · Aug 20, 2020Microbiology