A. S. Lauring

Antigenicity and receptor affinity of SARS-CoV-2 BA.2.86 spike

This paper evaluates the antigenicity and receptor affinity of the SARS-CoV-2 BA.2.86 subvariant, finding it not more resistant to human sera than other variants but with specific mAb resistance and high receptor affinity.

Deep mutational scanning reveals the functional constraints and evolutionary potential of the influenza A virus PB1 protein

This study uses deep mutational scanning to analyze the functional constraints and evolutionary potential of the influenza A virus PB1 protein by measuring replicative fitness across most possible amino acid substitutions.

Evolving antibody evasion and receptor affinity of the Omicron BA.2.75 sublineage of SARS-CoV-2

The paper analyzes the receptor affinity and antibody evasion properties of SARS-CoV-2 BA.2.75 subvariants, identifying two evolutionary pathways and three mutations that influence their virological features.

Type I interferon signaling induces a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection

This study identifies type I interferon signaling as inducing a delayed antiproliferative response in Calu-3 cells during SARS-CoV-2 infection, which may impair alveolar regeneration.

Mutual information networks reveal evolutionary relationships within the influenza A virus polymerase

This study uses mutual information networks to analyze coevolutionary relationships among residues in the influenza A virus polymerase, revealing functional interactions and host adaptability factors.

A rapid and flexible microneutralization assay for serological assessment of influenza viruses

The paper introduces a luciferase-based microneutralization assay (LMN) that correlates with HAI titers and can detect antigenic differences between egg-adapted and cell-derived influenza strains.

Bivalent mRNA vaccine improves antibody-mediated neutralization of many SARS-CoV-2 Omicron lineage variants

This study evaluates the neutralizing antibody response to bivalent mRNA vaccines against multiple Omicron variants, showing enhanced neutralization against BQ.1 and BQ.1.1.

Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants

The paper investigates the transmission bottlenecks of SARS-CoV-2 variants and finds that highly transmissible variants have tighter bottlenecks, limiting the spread of mutations.

Pre-existing immunity provides a barrier to airborne transmission of influenza viruses

The paper shows that pre-existing non-neutralizing immunity in ferrets blocks airborne transmission of seasonal influenza viruses.

Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts

This study analyzes SARS-CoV-2 mutation accumulation within and across infected hosts, finding low intrahost diversity and limited shared variants between unrelated individuals.

The effective population size and mutation rate of influenza A virus in acutely infected individuals

The paper estimates the within-host effective population size and mutation rate of influenza A virus in acute infections using sequence data from 200 patients.

The early evolution of oral poliovirus vaccine is shaped by strong positive selection and tight transmission bottlenecks

This study uses high-depth genome sequencing to analyze the early evolution of monovalent OPV2 in vaccinated individuals and their contacts, revealing strong positive selection and tight transmission bottlenecks.

Influenza B viruses exhibit lower within-host diversity than influenza A viruses in human hosts

This study compares within-host genetic diversity between influenza B and A viruses, finding lower diversity in B viruses and a tight transmission bottleneck.

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.

Stochastic processes dominate the within and between host evolution of influenza virus

This study uses viral sequence data from a community-based cohort to estimate within-host population dynamics and transmission bottlenecks of influenza A virus, finding that stochastic processes dominate its evolution.

Epistatic interactions within the influenza virus polymerase complex mediate mutagen resistance and replication fidelity

The paper identifies mutagen-resistant mutations in the influenza virus polymerase complex and shows how epistatic interactions between mutations affect replication fidelity and drug resistance.

The mutation rates and mutational bias of influenza A virus

This study measures the mutation rates and mutational bias of influenza A virus using a novel fluctuation test, finding higher rates than previous estimates and a strong transition-to-transversion bias.

Vaccination has minimal impact on the intrahost diversity of H3N2 influenza viruses

This study examines the effect of seasonal influenza vaccination on intrahost diversity of H3N2 viruses using whole genome sequencing and finds minimal impact.