T. Ahmed

GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors

This paper shows that activating GABA(A) receptors in lung cancer cells triggers autophagy via GABARAP-Nix interaction, enhancing radiation sensitivity and reducing toxicity in preclinical models.

Prevotella copri-related effects of a therapeutic food for malnutrition

The paper investigates the role of Prevotella copri in mediating the metabolic effects of a therapeutic food for malnutrition using gnotobiotic mouse models and multi-omics analyses.

ER structural remodeling requires TAK1/ATAT1-induced microtubule acetylation

The paper shows TAK1 activates TAT1 to acetylate microtubules, promoting ER tubulation and cell survival by downregulating BOK.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma

This study identifies IL-33 as a key driver of neutrophilic inflammation and NETosis in rhinovirus-induced asthma exacerbations, showing that blocking IL-33 reduces exacerbation severity.

Comprehensive multi-omics characterization of gut microbiome extracellular vesicles reveals a connection to gut-brain axis signaling

This study characterizes gut microbiome extracellular vesicles through multi-omics approaches, revealing their role in delivering neuroactive molecules across gut and blood-brain barriers.

Delivery of loaded MR1 Monomer Results in Efficient Ligand Exchange to Host MR1 and Subsequent MR1T cell activation

The paper demonstrates that delivering MR1 monomers loaded with 5-OP-RU enables ligand exchange to host MR1, leading to MR1T cell activation.

Identification of Mfn2-S249 as a Phosphoregulatory Switch of Mitochondrial Fusion Dynamics

The paper identifies Mfn2-S249 as a phosphoregulatory switch controlling mitochondrial fusion dynamics through TAK1-mediated phosphorylation, affecting mitochondrial morphology and energy homeostasis.

U2AF1 is a haplo-essential gene required for cancer cell survival

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Use of eVLP-based vaccine candidates to broaden immunity against SARS-CoV-2 variants

This study evaluates eVLP-based vaccine candidates against SARS-CoV-2 variants, showing that a trivalent vaccine induces broader immunity compared to single-variant vaccines.

An enveloped virus-like particle vaccine expressing a stabilized prefusion form of the SARS-CoV-2 spike protein elicits potent immunity after a single dose.

This paper evaluates an enveloped virus-like particle vaccine, VBI-2902a, which elicits strong immunity against SARS-CoV-2 after a single dose in mice and hamsters.

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

Structure of the ancestral TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

The paper presents the cryo-EM structure of TRPY1, revealing lipid and calcium modulation mechanisms.

The early evolution of oral poliovirus vaccine is shaped by strong positive selection and tight transmission bottlenecks

This study uses high-depth genome sequencing to analyze the early evolution of monovalent OPV2 in vaccinated individuals and their contacts, revealing strong positive selection and tight transmission bottlenecks.

Spatial Distribution of Discarded Vehicle Tires and Their Influence on Aedes albopictusand Culex quinquefasciatus Populations in New Orleans, Louisiana

The paper assesses the spatial distribution of discarded tires and their impact on mosquito populations in New Orleans using geospatial analysis and regression.

Breeding behaviour and productivity of Black-necked crane (Grus nigricolis) in Ladakh, Indian Trans-Himalaya

This study examines the breeding behavior and productivity of Black-necked cranes in Ladakh, finding stable population trends and specific breeding season patterns.

ENVELOPED VIRUS-LIKE PARTICLES (eVLPs) EXPRESSING MODIFIED FORMS OF ZIKA VIRUS PROTEINS E AND NS1 PROTECT MICE FROM ZIKA VIRUS INFECTION

This paper develops and tests bivalent eVLP vaccines expressing modified ZIKV E and NS1 proteins, showing 100% protection in mice against ZIKV challenge.

Different features of cholera in malnourished and non-malnourised children: analysis of 10-year surveillance data from a large diarrheal disease hospital in urban Bangladesh

This study compares clinical features of cholera in malnourished and non-malnourished children using surveillance data from Bangladesh, finding differences in presentation and hospitalization.