Author

M. Tien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. T. Anderson· 4 shared D. Nong· 4 shared W. O. Hancock· 4 shared Z. K. Haviland· 4 shared N. Zexer· 2 shared D. J. Cosgrove· 1 shared D. Ma· 1 shared K. O. Vasquez Kuntz· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersPlant Biology

C. T. Anderson

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Author profile →

4 papers

Recent·Most cited

Lignin impairs Cel7A degradation of cellulose by impeding enzyme movement and not by acting as a sink

Z. K. Haviland, D. Nong, N. Zexer, M. Tien, C. T. Anderson, W. O. Hancock

This study uses single-molecule fluorescence microscopy to show that lignin impairs Cel7A degradation of cellulose by blocking access and hindering enzyme movement, rather than acting as a sink.

bioRxiv · Aug 23, 2023 · PreprintPlant Biology

Single-molecule tracking reveals dual front door/back door inhibition of Cel7A cellulase by its product cellobiose

D. Nong, Z. K. Haviland, N. Zexer, S. A. Pfaff, D. J. Cosgrove, M. Tien, C. T. Anderson, W. O. Hancock

This study uses single-molecule tracking to show that cellobiose inhibits Cel7A cellulase by binding to both the product release site and the substrate binding tunnel.

bioRxiv · Jul 13, 2023Plant Biology

An integrated multi-wavelength SCATTIRSTORM microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

D. Nong, Z. K. Haviland, K. O. Vasquez Kuntz, M. Tien, C. T. Anderson, W. O. Hancock

The paper introduces a multimodal microscope combining IRM and TIRFM to image processive enzymes with high precision.

bioRxiv · Feb 25, 2021Biophysics

Nanoscale dynamics of cellulase TrCel7A digesting cellulose

Z. K. Haviland, D. Nong, K. Vasquez Kuntz, T. J. Starr, D. Ma, M. Tien, C. T. Anderson, W. O. Hancock

This study uses single-molecule tracking to analyze the dynamics of TrCel7A cellulase binding and movement along cellulose, revealing a three-state model with static and processive states.

bioRxiv · Feb 18, 2021 · PreprintPlant Biology