D. Ma

Comparison of black soldier fly, cricket, and superworm on growth performance, nutrient utilization and fatty acid profiles of rainbow trout

This study evaluates the effects of black soldier fly, cricket, and superworm meals on rainbow trout growth, nutrient utilization, and fatty acid profiles, finding no significant differences in growth but improved phosphorous utilization.

Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

This study evaluates the biological activity of 60c, a next-generation colchicine-binding site inhibitor, showing improved potency and anti-metastatic effects in triple-negative breast cancer models.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Ultraviolet attenuates centromere-mediated meiotic genome stability and alters gametophytic ploidy consistency in flowering plants

This study shows UV radiation reduces crossover rates and disrupts meiotic spindle organization in Arabidopsis, leading to unreduced gametes and altered genome stability.

Lateral Flow Assays Biotesting by Utilizing Plasmonic Nanoparticles Made of Inexpensive Metals - Replacing Colloidal Gold

This paper develops plasmonic nanoparticles made from inexpensive metals for lateral flow assays, showing they perform as well as or better than gold nanoparticles in biosensing.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

Dense Sampling of Taxa and Genomes Untangles the Phylogenetic Backbone of a Non-model Plant Lineage Rife with Deep Hybridization and Allopolyploidy

The paper constructs a robust phylogenetic backbone for the Campanuleae tribe using genomic data and phylogenetic methods, revealing hybridization and allopolyploidy as key drivers of diversification.

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

Single-nucleus RNA Sequencing and Spatial Transcriptomics Reveal the Immunological Microenvironment of Cervical Squamous Cell Carcinoma

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization

This study identifies α-taxilin and γ-taxilin as new components of centriolar subdistal appendages, showing their role in microtubule anchorage and spindle orientation.

Salt-induced first-order structural transition in a DNA-interacting protein

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

A novel, anatomy-similar in vitro model of 3D airway epithelial for anti-coronavirus drug discovery

This study develops a 3D airway epithelial ALI model to study coronavirus infection and drug efficacy, finding it mirrors human airway responses and drug effects.

Nanoscale dynamics of cellulase TrCel7A digesting cellulose

This study uses single-molecule tracking to analyze the dynamics of TrCel7A cellulase binding and movement along cellulose, revealing a three-state model with static and processive states.

Sub-diffraction error mapping for localization microscopy images

The paper introduces HAWKMAN, a method to map and quantify artificial sharpening errors in localization microscopy images using Haar wavelet kernel analysis.

Effect of SARS-CoV-2 spike mutations on animal ACE2 usage and in vitro neutralization sensitivity

This study evaluates how SARS-CoV-2 variants bind animal ACE2 proteins and their sensitivity to neutralizing antibodies and ACE2-Ig constructs, finding increased ACE2 affinity and partial resistance to antibodies but enhanced neutralization by ACE2-Ig.

A De Novo regulation design shows an effectiveness in altering plant secondary metabolism

This study designs a de novo regulation system using TFs and CREs to alter plant secondary metabolism, showing reduced tobacco alkaloids and nitrosamines in engineered plants.

Imaging transmembrane dynamics of biomolecules at live cell plasma membranes using quenchers in extracellular environment

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

Patient-derived xenograft culture-transplant system for investigation of human breast cancer metastasis

This paper develops a 3D tumor sphere culture-transplant system to study human breast cancer metastasis using patient-derived xenografts and validates its utility for functional metastasis assays.

Genotypic diversity between surgical and nasal Staphylococcus aureus isolates

The paper compares genotypic diversity between nasal and surgical Staphylococcus aureus isolates, finding greater diversity in PJI isolates and associations with immune status and virulence.

Potential host range of multiple SARS-like coronaviruses and an improved ACE2-Fc variant that is potent against both SARS-CoV-2 and SARS-CoV-1

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

eIF5a reduction via decreased Klf5 leads to cell senescence by mitochondrial fission in VSMCs

This study shows that Klf5 downregulation in VSMCs leads to mitochondrial fission and senescence by reducing eIF5a, which preserves mitochondrial integrity.

Hsa_circ_0001947 suppresses acute myeloid leukemia progression by sponging hsa-miR-329-5p and regulating CREBRF expression

This study identifies hsa_circ_0001947 as a tumor suppressor in AML that inhibits cell proliferation and drug resistance by sponging hsa-miR-329-5p and regulating CREBRF expression.

Three dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval

This paper introduces a method to achieve high-precision 3D nanoscopy across whole cells and tissues by retrieving the in situ point spread function from single-molecule data.

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.

The Toxin Antitoxin MazEF Drives Staphylococcus aureus Chronic Infection

This study shows that the MazEF toxin-antitoxin system in S. aureus inhibits biofilm formation and promotes antibiotic tolerance, facilitating the transition from acute to chronic infection.

Mono-homologous linear DNA recombination by the non-homologous end-joining pathway as a novel and simple gene inactivation method: a proof of concept study in Dietzia sp. DQ12-45-1b

This paper demonstrates a novel gene inactivation method using NHEJ-mediated mono-homologous linear DNA recombination in Dietzia sp. DQ12-45-1b, showing its potential for broad application in prokaryotes.

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques

This study evaluates the effectiveness of maraviroc in preventing oral SIV transmission to infant macaques, finding only marginal impact despite CCR5 blockade.