Breast cancer dormancy is associated with a 4NG1 state and not senescence
C. Prunier, A. Alay, M. van Dijk, K. L. Ammerlaan, S. van Gelderen, D. L. Marvin, A. Teunisse, R. C. Slieker, K. Szuhai, A. G. Jochemsen, X. Sole, P. ten Dijke, L. Ritsma
The paper characterizes breast cancer dormancy in cell lines, showing D2.OR cells enter a 4NG1 state rather than senescence, and can be reversed.
bioRxiv · Nov 20, 2020Cell Biology