P. ten Dijke

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

This study creates a spatial proteogenomic atlas of the liver across species, identifying conserved macrophage niches and their regulatory mechanisms.

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

The paper characterizes breast cancer dormancy in cell lines, showing D2.OR cells enter a 4NG1 state rather than senescence, and can be reversed.

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

This study identifies cercosporamide as a BMP type I receptor kinase inhibitor that rescues developmental defects in zebrafish embryos.

This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.

This paper develops a fluorescent small-molecule probe to monitor UCHL1 activity in live cells and zebrafish embryos, showing specificity for UCHL1 over other DUBs.