A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers
T. Hwang, S. S. Parker, S. M. Hill, M. W. Ilunga, R. A. Grant, G. Mouneimne, A. E. Keating
The paper identifies a conformational mechanism enabling specificity in ENAH EVH1 binding to PCARE, and designs a highly selective inhibitor.
bioRxiv · May 27, 2021Biochemistry