Author

T. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. E. Keating· 2 shared M. W. Ilunga· 2 shared R. A. Grant· 2 shared S. Kim· 2 shared A. F. Groff· 1 shared A. J. Wagers· 1 shared A. Jolly· 1 shared A. Williams· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

A. E. Keating

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Author profile →

5 papers

Recent·Most cited

High-throughput Microfluidic 3D Outer Blood-Retinal Barrier Model in a 96-Well Format: Analysis of Cellular Interactions and Barrier Function in Retinal Health and Disease

J. Kim, Y. Song, A. Jolly, T. Hwang, S. Kim, B. Lee, J. Jang, D. H. Jo, K. Baek, T.-L. Liu, S. Yoo, N. L. Jeon

bioRxiv · Dec 1, 2023Bioengineering

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

T. Hwang, S. S. Parker, S. M. Hill, M. W. Ilunga, R. A. Grant, G. Mouneimne, A. E. Keating

The paper identifies a conformational mechanism enabling specificity in ENAH EVH1 binding to PCARE, and designs a highly selective inhibitor.

bioRxiv · May 27, 2021Biochemistry

Native proline-rich motifs exploit sequence context to target actin-remodeling Ena/VASP proteins

T. Hwang, R. A. Grant, M. W. Ilunga, V. Sivaraman, A. E. Keating

The paper identifies how proline-rich motifs interact with ENAH EVH1 domain through sequence context, revealing extended SLiMs and their role in protein-protein interactions.

bioRxiv · Mar 22, 2021Biochemistry

The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis

J. P. Lewandowski, J. C. Lee, T. Hwang, H. Sunwoo, J. M. Goldstein, A. F. Groff, N. Chang, W. Mallard, A. Williams, J. Henao-Meija, R. A. Flavell, J. T. Lee, C. Gerhardinger, A. J. Wagers, J. L. Rinn

This study shows that the Firre locus produces a trans-acting RNA involved in hematopoiesis and immune function, as demonstrated through genetic models and functional assays.

bioRxiv · May 24, 2019Immunology

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced de-novo mutation in survival outliers of glioblastoma

T. Hwang, D. Mathios, K. L. McDonald, I. Daris, S.-H. Park, P. C. Burger, S. Kim, Y.-S. Dho, H. Carolyn, C. Bettegowda, J. H. Shin, M. Lim, C.-K. Park

The paper analyzes DNA methylation in glioblastoma survivors to identify distinct methylation patterns linked to oncogenic pathways and mutation rates.

bioRxiv · Apr 16, 2018Cancer Biology