Perturbed actin cap and nuclear morphology in primary fibroblasts of Huntington's disease patients as a new phenotypic marker for personalized drug evaluation
S. Gharaba, O. Paz, L. Feld, A. Abashidze, M. Weinrab, H. Wolfenson, M. Weil
This study identifies a distinctive nuclear morphology and actin cap deficiency in HD fibroblasts, which can be modulated by drugs and used as a phenotypic marker for personalized drug evaluation.
bioRxiv · Apr 3, 2022 · PreprintCell Biology