Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion
R. Kudo, A. Safonov, E. M. da Silva, Q. Li, H. Shao, M. Will, A. Fushimi, H. Nakshatri, J. S. Reis-Filho, S. Goel, A. Koff, B. Weigelt, Q. J. Khan, P. Razavi, S. Chandarlapaty
The paper identifies TP53 loss and MDM2 amplification as factors associated with poor long-term response to CDK4/6 inhibition in breast cancer and shows that CDK2 inhibition can overcome this resistance.
bioRxiv · Aug 25, 2023Cancer Biology