S. Goel

Characterization and classification of fine-resolution soil profile for precision agriculture using random forest and self-organizing map

This study uses random forest and self-organizing map models to classify fine-resolution soil profiles for precision agriculture, finding random forest achieves over 85% prediction accuracy.

Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion

The paper identifies TP53 loss and MDM2 amplification as factors associated with poor long-term response to CDK4/6 inhibition in breast cancer and shows that CDK2 inhibition can overcome this resistance.

De Novo Design of Peptide Binders to Conformationally Diverse Targets with Contrastive Language Modeling

This paper designs short, target-binding linear peptides using a contrastive learning framework, demonstrating effective binding and degradation of conformationally diverse proteins.

NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

This study identifies a NF-κB-independent role of NEMO in proteostasis by promoting aggrephagy through co-condensation with p62.

Reovirus sensitizes microsatellite stable colorectal cancer to anti-PD-1 treatment via cross-talk in innate and adaptive immune systems

This study shows that reovirus enhances anti-PD-1 treatment effectiveness in microsatellite stable colorectal cancer by modulating innate and adaptive immune responses.

Transcriptional network involving ERG and AR orchestrates Distal-Less Homeobox 1 mediated prostate cancer progression.

The paper identifies a transcriptional network involving ERG, AR, and DLX1 in prostate cancer progression and shows BET inhibitors can target this network.

Membrane integration and topology of RIFIN and STEVOR proteins of the Plasmodium falciparum parasite

The paper investigates the membrane topology of RIFIN and STEVOR proteins in Plasmodium falciparum using N-linked glycosylation to determine their ER membrane insertion patterns.

Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer.

This study identifies miRNA-338-5p and miRNA-421 as epigenetically silenced in SPINK1-positive prostate cancer, and shows their restoration inhibits oncogenic properties.