H. Shao

Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion

The paper identifies TP53 loss and MDM2 amplification as factors associated with poor long-term response to CDK4/6 inhibition in breast cancer and shows that CDK2 inhibition can overcome this resistance.

Spatio-temporal variation of bacterial community structure in two intertidal sediment types of Jiaozhou Bay

This study examines bacterial community structure in intertidal sediments of Jiaozhou Bay, finding that sandy sediments have more species involved in community building and that temporal changes have a greater impact on bacterial communities than on gene families.

Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly

The paper determines cryo-EM structures of a mtHsp60 mutant to show how apical domains coordinate client engagement and chaperonin assembly during the ATP-dependent cycle.

Maintaining hypoxia environment of subchondral bone alleviates osteoarthritis progression

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

A CXCR3-activating peptide increases Tear Break Up Time and corrects corneal haze in a rabbit model of environmental dry eye

A CXCR3-activating peptide improves tear quality and reduces corneal haze in a rabbit model of environmental dry eye without affecting tear volume.

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.

A high-throughput compound screen identified JG98 and parthenolide as reducing MyBP-C levels, revealing the Hsp70-BAG3 complex as a regulator of MyBP-C stability in HCM.

Axl contributes to efficient migration and invasion of melanoma cells

This study investigates Axl's role in melanoma cell migration and invasion, finding that Axl inhibition reduces these processes in vitro.

Elevated transcriptional pausing of RNA polymerase II underlies acquired resistance to radiotherapy

This study identifies increased RNA polymerase II pausing as a mechanism of acquired radiotherapy resistance in cancer cells and suggests CDK7 inhibitors as a potential therapeutic strategy.

ARID1A loss derepresses human endogenous retrovirus-H to modulate BRD4-dependent transcription

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

Lactobacilli and other gastrointestinal microbiota of Peromyscus leucopus, reservoir host for agents of Lyme disease and other zoonoses in North America

The paper characterizes the gut microbiota of Peromyscus leucopus, identifying Lactobacillus species and other microbes, and highlights differences from Mus musculus.

Adenosine tips the pathogenic Th1 and Th17 responses in experimental autoimmune uveitis (EAU)

This study shows adenosine enhances Th17 responses while inhibiting Th1 responses in experimental autoimmune uveitis, affecting immune balance through γδ T cells and dendritic cells.

Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma

This study identifies allosteric HSP70 inhibitors that overcome proteasome inhibitor resistance in multiple myeloma by targeting mitochondrial HSPA9 and disrupting mitoribosome stability.

Adhesion-mediated mechanosignaling forces mitohormesis

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy

This study shows that inhibiting DNAJ-HSP70 interaction improves muscle strength in LGMD1D by re-mobilizing HSP70 and correcting myopathology.

Metagenomic characterization of the viral community of the South Scotia Ridge

This study characterizes the viral community of the South Scotia Ridge using metagenomic analysis, revealing novel viral sequences and high diversity.

The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.