Analysis of SIV Spatiotemporal Dissemination Patterns in Rhesus Macaques During Early Rectal Transmission Demonstrates Systemic Infection Does Not Require Viral Local Amplification at the Entry Portal
Yilun Cheng, Jackson Chen, Miaoyun Zhao, Subhra Mandal, Saroj Chandra Lohani, Qin Liu, Mark G. Lewis, Ma Luo, Michael Gale, Qingsheng Li
This study examines SIV dissemination in rhesus macaques after rectal infection, showing systemic infection occurs without local viral amplification at the entry site.
bioRxiv · Nov 12, 2025 · PreprintImmunology