Author

Mackenzie Welch

Biogen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

Aimee W. KaoiD· 1 shared Alix BoomsiD· 1 shared Allyson Cole-Strauss· 1 shared Andreas WeihofeniD· 1 shared Andy W. SmithiD· 1 shared Anuja BothraiD· 1 shared Apoorva Mohan· 1 shared Brian F. Daley· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Aimee W. KaoORCID

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2 papers

Recent·Most cited

A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis

Mackenzie Welch, Paul J. Sampognaro, Shunpan Shu, Kriti Chaplot, Anuja Bothra, Patricia A. Castruita, Andy W. Smith, Tara Antee, Molly Hodul, Ruilin Tian, Vienna Gao, Juanita C. Limas, Kevin D. Burris, Joanne L. Parker, Jennifer S. Yokoyama, , Aimee W. Kao

The paper identifies PQLC2 as a lysosomal pH regulator that affects tau homeostasis through a CRISPRi screen in iPSC-derived neurons.

bioRxiv · Aug 31, 2026 · PreprintNeuroscience

Alpha-synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease

Tracy A. Cole, Hien Tran Zhao, Timothy J. Collier, Ivette M. Sandoval, Caryl E. Sortwell, Kathy Steece‐Collier, Brian F. Daley, Alix Booms, Jack W. Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle L. Graham, Andreas Weihofen, Stephanie L. Celano, , Katrina L. Paumier

This paper demonstrates that antisense oligonucleotides targeting SNCA reduce alpha-synuclein production, prevent pathology, and show translational potential in non-human primates.

bioRxiv · Nov 4, 2019 · PreprintNeuroscience