Ivette M. Sandoval

Dual kinase inhibition provides early clues to restoration of neuroimmune homeostasis in an AAV-haSyn model of Parkinsons disease

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

Tau, amyloid-beta and alpha-synuclein co-pathologies synergistically enhance neuroinflammation and neuropathology

This paper shows that combined Alzheimer's and Parkinson's protein pathologies enhance neuroinflammation and neurodegeneration in a mouse model.

Tissue resident memory CD8+ T cells are present but not critical for demyelination and neurodegeneration in a mouse model of multiple system atrophy.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.

Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson’s Disease

This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.

Alpha-synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease

This paper demonstrates that antisense oligonucleotides targeting SNCA reduce alpha-synuclein production, prevent pathology, and show translational potential in non-human primates.