Metabolic engineering of Salmonella enterica for coupled kynurenine sensing and depletion enhances antitumor efficacy
Kontham Kulangara Varsha, Akeem Santos, Tingting Xiao, Zeneng Wang, Rashmi Bharti, Mahima Arora, Austin M Williams, John Peterson, Justin D. Lathia, Stanley L. Hazen, Nan Zhang, Philip P. Ahern, Ofer Reizes, Mohammed Dwidar
This paper engineers Salmonella enterica to sense and deplete kynurenine in tumors, enhancing antitumor immune responses and efficacy in mouse models.
bioRxiv · Sep 24, 2026 · PreprintCancer Biology