Ofer Reizes

This paper engineers Salmonella enterica to sense and deplete kynurenine in tumors, enhancing antitumor immune responses and efficacy in mouse models.

This study shows that spermidine, a metabolite from glioblastoma cells, suppresses CD8+ T cell function, promoting tumor growth and poor patient outcomes.

This study shows that MBOAT7 loss of function in hepatocytes causes ethanol-induced liver injury by disrupting lysosomal biogenesis and autophagic flux.