De novo chemo-optogenetics through rational small-molecule design and TRAP display
Tomoki Miyazaki, Tomoshige Fujino, Tatsuyuki Yoshii, Mamoru Funane, Naoya Murata, C. Kim, Satoru Nagatoishi, Kouhei Tsumoto, Gosuke Hayashi, Hiroshi Murakami, Shinya Tsukiji
This paper introduces a method to create synthetic chemo-optogenetic tools by combining rational small-molecule design with TRAP display to generate light-controlled protein binders.
bioRxiv · Apr 10, 2025 · PreprintSynthetic Biology