Shinya Tsukiji

This paper introduces a method to create synthetic chemo-optogenetic tools by combining rational small-molecule design with TRAP display to generate light-controlled protein binders.

This study shows low-affinity EGFRLs like EREG and AREG transmit signals more efficiently than high-affinity ligands during collective cell migration and wound healing.

The paper develops fluorescent PI4P reporters based on ORP9-PH domains to visualize PI4P dynamics in living cells across multiple locations with high specificity.

This study applies the SLIPT system to fission yeast to perturb cell cycle-related proteins with improved temporal resolution.

This paper develops synthetic protein condensates that can recruit or release protein activity in mammalian cells using small molecules or light.

This paper introduces a chemogenetic platform that enables rapid, reversible, and repeatable control of plasma membrane protein translocation using a novel engineered tag and ligand pair.