Dual-action nanoconjugate for overcoming r-tPA -resistant clots
Audrey Picot, Mandy Leboucher, Charly Hélaine, Ankita Talukdar, Igor Khalin, Sara Martínez de Lizarrondo, Maxime Gauberti, Mialitiana Solo Nomenjanahary, Didier Goux, Benoît Ho‐Tin‐Noé, Denis Vivien, Thomas Bonnard
This study develops a dual-action nanoconjugate combining r-tPA and DNase to target r-tPA-resistant clots, showing improved reperfusion and reduced lesion volume in an ischemic stroke model.
bioRxiv · May 21, 2026 · PreprintPathology