Ribosomal Biogenesis Hyperactivation and ErbB signalling Mediated Network Rewiring Causes Adaptive Resistance to FGFR2 Inhibition
Tao Zhang, Sung‐Young Shin, Callan McCrimmon, Mandy Theocharous, Ralf B. Schittenhelm, Thierry Jardé, Roger J. Daly, Lan K. Nguyen
This study identifies ribosomal biogenesis hyperactivation and ErbB signaling reactivation as mechanisms of resistance to FGFR2 inhibitors in breast cancer cells and shows synergy with MEK inhibitors.
bioRxiv · Oct 27, 2024 · PreprintCancer Biology