Roger J. Daly

This study shows PIEZO1 supports apoptotic cell extrusion by maintaining mechanical homeostasis rather than through calcium signaling.

This study identifies a novel feed-forward signalling axis between PEAK1 and CAMK2 in TNBC, showing that targeting CAMK2 can inhibit PEAK1-driven oncogenic processes.

This study identifies ribosomal biogenesis hyperactivation and ErbB signaling reactivation as mechanisms of resistance to FGFR2 inhibitors in breast cancer cells and shows synergy with MEK inhibitors.

This study generates Grb7 KO mice and shows Grb7 and Grb14 have minimal impact on fetal growth but Grb7 may promote kidney growth and subtly affects glucose metabolism in adults.

The paper develops a computational model of FGFR4 signalling to identify cell type-selective combination therapies for FGFR4-driven cancers, revealing AKT and ERK reactivation as key resistance mechanisms.

This study shows Snail induces cell extrusion through RhoA contractile signaling and reduced basal adhesion, independent of EMT.