Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling
Alexandre Pierga, Yan de Souza Angelo, Adham Safieddine, Marie‐Noëlle Benassy, Blaise Didry‐Barca, Marie Rozen, Luís Seabra, Claire Lovo, Sylvie Bannwarth, Sandra Lacas‐Gervais, Gittan Kollberg, Carola Hedberg Oldfors, Antria Savvidou, Dominique Barbieri-Weill, Yanick Joseph Crow, Alice Lepelley
This study shows that MTPAP loss causes mitochondrial RNA processing defects, leading to type I interferon signaling upregulation through mt-dsRNA accumulation.
bioRxiv · May 7, 2026 · PreprintCell Biology