Cell BiologybioRxivPreprint
Loss of MTPAP disrupts mitochondrial RNA processing causing upregulation of type I interferon signalling
Alexandre Pierga, Yan de Souza Angelo, Adham Safieddine…·Alice Lepelley
This study shows that MTPAP loss causes mitochondrial RNA processing defects, leading to type I interferon signaling upregulation through mt-dsRNA accumulation.
DOI 10.64898/2026.05.04.722669