Author

Mario O Caracci

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Identified by ORCID

Mario O CaracciiD1 paper · Max Planck Institute of Molecular Physiology;

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Birga SoetjeiD· 3 shared Kirsten MicheliD· 3 shared Luis Manuel Munoz-NavaiD· 3 shared Philippe I. H. BastiaensiD· 3 shared Sabrina SeidleriD· 3 shared Holger Vogel· 1 shared Janicke Maerz· 1 shared Kitso Ata KewagamangiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

Birga SoetjeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

EGF and EREG regulate early oncoprotein-mediated tissue transformation in intestinal organoids.

Mario O Caracci, Birga Soetje, Luis Manuel Munoz-Nava, Kirsten Michel, Sabrina Seidler, Petra Janning, Philippe I.H. Bastiaens

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

bioRxiv · Nov 9, 2026 · PreprintCancer Biology

Reversible Opto-Chemical activation of KRASG12V signaling with near single-cell precision

Luis Manuel Muñoz-Nava, Maria Bespalova, Mario O. Caracci, Kitso Ata Kewagamang, Birga Soetje, Sabrina Seidler, Kirsten Michel, Holger Vogel, Janicke Maerz, Philippe I. H. Bastiaens

This paper develops a reversible Opto-Chemical system to activate KRASG12V signaling with near single-cell precision and demonstrates its effects on epithelial transformation.

bioRxiv · Jul 7, 2026 · PreprintSystems Biology

Proliferation and differentiation in intestinal organoids as a balance of ligand-modulated EGFR trafficking

Mario O. Caracci, Sabrina Seidler, Luis Manuel Muñoz-Nava, Birga Soetje, Kirsten Michel, Philippe I. H. Bastiaens

This study shows that EGF and EREG ligands regulate proliferation and differentiation in mouse intestinal organoids by modulating EGFR endocytosis and surface expression.

bioRxiv · Apr 2, 2026 · PreprintDevelopmental Biology