Author

Mark Davies

Cardiff University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Assay:metabolomics· 1

Frequent Co-Authors

Ana P. GomesiD· 1 shared Andriy MarusykiD· 1 shared Daria MiroshnychenkoiD· 1 shared Derek R. DuckettiD· 1 shared Didem IlteriD· 1 shared Eduardo D. SontagiD· 1 shared Harsh Vardhan JainiD· 1 shared Hyo Sook HaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

Ana P. GomesORCID

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Author profile →

2 papers

Recent·Most cited

Ploidy shapes gemcitabine response through altered potency and delayed cell death

Vural Tagal, Jackson P. Cole, Tao Li, Rikhil J Kumar, Jordan Albrecht, Pujan Shrestha, Didem Ilter, Daria Miroshnychenko, Stanislav Drápela, Kayode D. Olumoyin, John Kyei, Mark Davies, Andriy Marusyk, Stuart R. Maudsley, Xiaoqing Yu, , Noemi Andor

This study shows that higher ploidy reduces gemcitabine potency and delays cell death by altering drug exposure kinetics and response timing.

bioRxiv · Sep 12, 2026 · PreprintCancer Biology

Delaying Cancer Progression by Integrating Toxicity Constraints in a Model of Adaptive Therapy

Jana L. Gevertz, Harsh Vardhan Jain, Irina Kareva, Kathleen P. Wilkie, Joel S. Brown, Yitong Huang, Eduardo D. Sontag, Vladimir Vinogradov, Mark Davies

This paper develops a mathematical model to assess how incorporating toxicity feedback affects adaptive cancer therapy, finding that toxicity-induced treatment breaks can extend time to progression.

npj Systems Biology and Applications · Jan 7, 2026Peer-reviewedSystems Biology