IDH1R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response
Felipe J. Núñez, Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri, Masha G. Savelieff, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Rohin Patel, Stephen Carney, Marissa Z. Guo, Maria B. Garcia-Fabiani, Santiago Haase, Marta Edwards, Mats Ljungman, , Maria G. Castro
The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.
bioRxiv · Aug 10, 2018 · PreprintCancer Biology