Cancer BiologybioRxivPreprint
IDH1R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response
Felipe J. Núñez, Flor M. Mendez, Padma Kadiyala…·Maria G. Castro
The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.
DOI 10.1101/389817