Author

Maria G. Castro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Pedro R. Lowenstein· 2 shared Alan Meeker· 1 shared Albert Lai· 1 shared Alvaro G. AlvaradoiD· 1 shared Anda-Alexandra Calinescu· 1 shared Brandon Gruender· 1 shared Cameron J. Herting· 1 shared Carl Koschmann· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Pedro R. Lowenstein

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2 papers

Recent·Most cited

Cancer BiologybioRxivNov 15, 2023

De novo lipogenesis pathway is a vulnerability in IDH1 mutant glioma

Lubayna S. Elahi, Michael C. Condro, Riki Kawaguchi…·Harley I. Kornblum

This study identifies de novo lipogenesis as a vulnerability in IDH1 mutant gliomas, showing that HDAC inhibition and FASN targeting reduce tumor growth and improve survival.

DOI 10.1038/s44324-024-00021-6

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 10, 2018

IDH1R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response

Felipe J. Núñez, Flor M. Mendez, Padma Kadiyala…·Maria G. Castro

The paper shows IDH1R132H mutation in glioma improves survival and DNA repair by enhancing ATM signaling and radioresistance, which can be reversed by inhibiting ATM or CHK1/2.

DOI 10.1101/389817

humanbulk RNA-seq

𝕏 PostBluesky