A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists
Warren T. Yacawych, Yi Wang, Guoxiang Zhou, Shad Hassan, Çağrı Bodur, Elisabeth Walters, John G. Santinga, Frederike Sass, Martin DeVaux, Stace Kernodle, Iris Wu, Jenny M. Brown, Dylan M. Belmont-Rausch, Alan C. Rupp, Abigail J. Tomlinson, , Weiwei Qiu
This study identifies a single dorsal vagal complex circuit that mediates both aversive and anorectic responses to GLP1R agonists, showing that APGlp1r neurons are responsible for both effects.
Journal of Clinical Investigation · Sep 15, 2026Peer-reviewedNeuroscience