Yi Wang

Single-cell transcriptome-wide Mendelian randomization and colocalization analyses reveal immune-cell-specific mechanisms and actionable drug targets in prostate cancer

The paper identifies immune-cell-specific genetic associations and drug targets in prostate cancer using integrative analyses of single-cell and bulk data.

InfluProto: Predicting Cross-Species Transmission of Influenza A Virus via Prototype Learning

InfluProto predicts cross-species transmission of influenza A virus using prototype learning, showing high accuracy in host classification and detecting reassortment effects.

A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists

This study identifies a single dorsal vagal complex circuit that mediates both aversive and anorectic responses to GLP1R agonists, showing that APGlp1r neurons are responsible for both effects.

The cellular and genetic basis of inflorescence divergence between maize and teosinte

This study identifies cellular and genetic changes in maize and teosinte ears, showing how cytokinin signaling and transcription factor expression differences drive cob thickening and increased kernel number during domestication.

Deanticoagulated heparins drive a novel repair-secretory epithelial program to restore mucosal barrier in ulcerative colitis

The paper identifies NALHP/S6, a heparin derivative, as a glycan-based modulator that restores mucosal barrier function in ulcerative colitis by promoting a repair-secretory epithelial state.

SMS: Symmetric Mediation Statistics for Powerful High-Dimensional Mediation Analysis

SMS improves high-dimensional mediation analysis by controlling FDR and increasing sensitivity, identifying mediators missed by existing methods in metabolomics and DNA methylation data.

In-situ Target Base Editing Combining with Biosensor-driven Strategy Reveals Critical Single Nucleotide Variants for Enhanced Recombinant Protein Secretion in Pichia pastoris

The paper develops a strategy combining genome editing and biosensor-assisted sorting to identify SNVs enhancing recombinant protein secretion in Pichia pastoris, achieving a high rHSA titer.

Impairing NK-mediated immune rejection through NKG2DL editing to improve CAR-T cell persistence

This study shows that editing ULBP ligands reduces NK cell rejection of UCAR-T cells, improving their persistence and antitumor efficacy.

Metabolic reinvigoration of NK cells by IL-21 enhances immunotherapy against MHC-I deficient solid tumors

This paper shows that IL-21-Fc reprograms NK cell metabolism to enhance their function against MHC-I deficient tumors, leading to tumor eradication in preclinical models.

Orally surface engineered probiotic system for ulcerative colitis therapy via modulating gut microbiota and immune homeostasis

This paper develops a probiotic system for ulcerative colitis that enhances probiotic survival and colon targeting, modulates gut microbiota and immune responses, and provides a mathematical model for release dynamics.

Spatially-resolved molecular sex differences at single cell resolution in the adult human ventromedial and arcuate hypothalamus

The paper creates a single-cell atlas of sex-differentially expressed genes in human hypothalamus regions, revealing molecular sex differences and their links to neurodevelopmental disorders.

Using gnotobiotic mice to decipher effects of gut microbiome repair in undernourished children on tuft and goblet cell function

This paper uses gnotobiotic mice to model microbiome repair effects in undernourished children, revealing changes in gut cell function and microbial gene expression.

Enhancing Volatile Fatty Acid Accumulation in Seaweed-Arrested Anaerobic Digestion via a Two-Tier Framework of Engineering Diagnostics and Microbial Surveillance

Genome-enabled stilbenoid gene cluster discovery in Pleuropterus multiflorus

The paper identifies a novel stilbenoid biosynthetic gene cluster in Pleuropterus multiflorus using genome sequencing and analysis, revealing key enzymes and regulatory mechanisms.

Identification of Intrinsic Features for Cortical Separability of Human and Mouse Neurons

This paper identifies intrinsic features that distinguish human and mouse cortical neurons, revealing significant differences in morphology, function, and separability across brain regions.

A novel bifunctional peptide VAMP mined from hemp seed protein hydrolysates improves glucose homeostasis by inhibiting intestinal DPP-IV and increasing the abundance of Akkermansia muciniphila

The paper identifies a novel tetrapeptide VAMP from hemp seed protein hydrolysates that inhibits DPP-IV and increases Akkermansia muciniphila abundance, improving glucose homeostasis in obese mice.

Zebrafish airinemes optimize their shape between ballistic and diffusive search

The paper shows zebrafish airinemes balance ballistic and diffusive search to optimize target cell contact probability.

Co-expression analysis is biased by a mean-correlation relationship

The paper identifies a mean-correlation relationship in RNA-seq data that biases co-expression analysis and introduces SpQN to correct this bias in network reconstruction.

Investigating the Evolutionary Importance of Denisovan Introgressions in Papua New Guineans and Australians

This study identifies Denisovan introgressions in Papua New Guineans and Australians, finds they are under positive selection and related to important evolutionary functions, and proposes a method for detecting archaic hominin introgressions.