Effect of selective lesions of nucleus accumbens μ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1-Cre knock-in rats
Jennifer M. Bossert, Carlos A. Mejías-Aponte, Thomas L. Saunders, Lindsay Altidor, Michael A. Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey F. Seasholtz, Elizabeth Hughes, , Yavin Shaham
This study introduces a CRISPR-based Oprm1-Cre knock-in rat to investigate the role of nucleus accumbens MOR-expressing cells in heroin self-administration, finding sex-specific effects on acquisition and effort.
Journal of Neuroscience · Jan 30, 2023Peer-reviewedNeuroscience