Author

Matthew MacAinsh

University of Illinois Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

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Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Approach:statistical model· 1

Frequent Co-Authors

Huan‐Xiang ZhouiD· 2 shared Sanbo QiniD· 1 shared Souvik DeyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

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3 top collaborators · 2 mutual co-author links

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2 shared papersBiophysics

Huan‐Xiang ZhouORCID

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2 papers

Recent·Most cited

DIRseq: a method for predicting drug-interacting residues of intrinsically disordered proteins from sequences

Matthew MacAinsh, Sanbo Qin, Huan‐Xiang Zhou

DIRseq predicts drug-interacting residues in intrinsically disordered proteins from sequences, showing good agreement with experimental methods like NMR and MD simulations.

bioRxiv · May 2, 2025Biophysics

Direct and Indirect Salt Effects on Homotypic Phase Separation

Matthew MacAinsh, Souvik Dey, Huan‐Xiang Zhou

This study investigates how salt affects the phase separation of hnRNPA1's low-complexity domain, finding that NaCl promotes phase separation by neutralizing charge and bridging protein chains.

eLife · Aug 12, 2024Peer-reviewedBiophysics