Huan‐Xiang Zhou

This study shows that protamines, despite being intrinsically disordered, bind DNA with nucleobase-specific preferences, favoring GC over AT in the major groove and vice versa in the minor groove.

The paper identifies sequence determinants for aromatic residue insertion into membranes and develops a predictor model with high accuracy.

This study shows HMGB1 counteracts protamine to maintain liquid DNA condensates, facilitating DNA repair by preventing tangle formation.

The paper identifies a biofilm-derived peptide from Vibrio cholerae that adheres to surfaces and functions as a wet adhesive and flocculant, with potential for industrial and biomedical applications.

The paper shows that backbone hydrogen bonding determines condensate material states, as demonstrated by experiments with tetrapeptides and simulations.

The paper investigates how a Vibrio cholerae peptide binds lipids through a β-hairpin conformation, contributing to biofilm adhesion and host colonization.

This study uses MD simulations and FLIM-FRET to show Dsup binds DNA in living cells and enhances cell survival under oxidative stress in mammalian and yeast cells.

This paper measures bridging forces in protein-DNA condensates using optical tweezers and shows that the ssDNA-to-dsDNA ratio affects force magnitude.

The paper develops a method to calculate small-angle scattering profiles of dense protein solutions using precomputed pair interactions, revealing dimer populations in bovine serum albumin at high concentrations.

The paper identifies correlated segments in intrinsically disordered proteins as key drivers of homotypic phase separation, showing that these segments, not individual residues, are responsible for the phenomenon.

DIRseq predicts drug-interacting residues in intrinsically disordered proteins from sequences, showing good agreement with experimental methods like NMR and MD simulations.

This study determines the structure of Mycobacterium tuberculosis CrgA, revealing its dimeric form and interactions with divisome proteins essential for cell division.

This study uses MD simulations to characterize membrane-assisted Aβ40 aggregation pathways, revealing key intermediates and stabilization roles of specific residues and lipids.

This study investigates how protamine compacts DNA through multiple modes, forming bends, loops, and coils that contribute to transcription silencing in sperm cells.

This study investigates how different amino acids affect the physical properties of tetrapeptide condensates, revealing significant variations in phase behavior and material properties.

This study investigates how salt affects the phase separation of hnRNPA1's low-complexity domain, finding that NaCl promotes phase separation by neutralizing charge and bridging protein chains.

The paper introduces FMAPS(q), a method to calculate protein solution structure factors using atomistic modeling of protein-protein interactions, showing agreement with experimental scattering data.

The paper identifies a conserved glycine in NMDA receptors that influences slow deactivation and high Ca2+ permeability through structural changes caused by disease-associated mutations.