Engineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation
Mark Knappenberger, Skylar J.W. Henry, Archana Kikla, Matthew Sample, Olivia Roy, Erik Poppleton, Nicholas Stephanopoulos, Michael P. Gustafson, Karen S. Anderson, Petr Šulc
This paper introduces mRNA-OG, a programmable mRNA nanostructure that affects protein expression, delivery, and immune response through its architecture.
bioRxiv · Sep 17, 2026 · PreprintBioengineering