Nicholas Stephanopoulos

This paper introduces mRNA-OG, a programmable mRNA nanostructure that affects protein expression, delivery, and immune response through its architecture.

This paper constructs dynamic DNA origami assemblies using coiled-coil peptides to create reconfigurable structures with tunable mechanical properties.

This paper describes a method using DNA origami to guide the assembly of protein-DNA conjugates into programmable nanostructures with controlled stoichiometry and geometry.

This paper demonstrates the site-specific arrangement and structural determination of minor groove binding molecules in self-assembled DNA crystals using x-ray crystallography.

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.

This study develops a DNA-based hydrogel platform to control the temporal presentation of biomolecules, showing delayed osteogenic growth peptide (OGP) delivery increases alkaline phosphatase activity during osteogenesis.

This paper develops a calcium-triggered DNA-mediated membrane fusion strategy using surface-bound PEG chains cleavable by calpain-1.