Locus Coeruleus activity correlates with transient elevations in breathing during opioid-induced respiratory depression
Caroline C. Szujewski, Jaseph Soto-Perez, Anmin Yang, Matthew Warden, Shivang Sullere, Gia E. Fisher, Joseph V Gogola, Alfredo J. Garcia
This study shows that fentanyl increases locus coeruleus bursts and transient breathing elevations, with divergent respiratory responses after repeated opioid use.
bioRxiv · Nov 3, 2026 · PreprintPhysiology