DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture
Noah Hitchcock, Maxine Annoh, Luigi Grassi, Samik Das, Cristina Sayago Ferreira, Daniel Ray, Ramy Elgendy, Lin Wang, Ken Lee, Ian M. Sudbery, Daniel A. Bose, Diane Hatton, Si Nga Sou, Rajesh K. Mistry, Christopher P. Toseland
The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.
bioRxiv · Mar 19, 2026 · PreprintCell Biology