Author

Ken Lee

AstraZeneca (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro Z. Bihun· 1 shared Alexandra Hoff· 1 shared Amanda Kelley· 1 shared Arpa EbrahimiiD· 1 shared Ashley Hoff· 1 shared Benjamin Hagen· 1 shared Christopher P. ToselandiD· 1 shared Claudia S. MaieriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Alejandro Z. Bihun

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Author profile →

2 papers

Recent·Most cited

DNA Damage Driven Viability Loss and Transcriptional Reprogramming in Chinese Hamster Ovary Cell Perfusion Culture

Noah Hitchcock, Maxine Annoh, Luigi Grassi, Samik Das, Cristina Sayago Ferreira, Daniel Ray, Ramy Elgendy, Lin Wang, Ken Lee, Ian M. Sudbery, Daniel A. Bose, Diane Hatton, Si Nga Sou, Rajesh K. Mistry, Christopher P. Toseland

The paper identifies DNA damage accumulation as a key factor limiting viability in Chinese hamster ovary cells during perfusion culture, showing impaired DNA damage response and transcriptional dysfunction.

bioRxiv · Mar 19, 2026 · PreprintCell Biology

Appearance of Amyloid-β Early in Life Initiates Neuronal Hyper-excitability, Mitochondrial Decay, and Loss of Dendritic Complexity in the Hippocampal CA1 Region of 5xFAD Mice

Amanda Kelley, Emily Denise Sackinger, Mathew Frischman, Nicholas O. Thomas, Kaitlyn Kim, Grace Scuderi, Edwin M. Labut, Duncan MacMurchy, Toren Ikea-Mario, Jacob Rauenhorst, Easton Neitzel, Tacita Vu, Leda Liko, Alexandra Hoff, Ashley Hoff, , Tory M. Hagen

This study identifies early synaptic and metabolic dysfunctions in 5xFAD mice before plaque formation, linking them to hippocampal vulnerability in Alzheimer's disease.

bioRxiv · Feb 6, 2026 · PreprintNeuroscience