S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity
Xu Zhang, Roman Vlkolinský, Chongyang Wu, Nima Dolatabadi, Henry R. Scott, Olga Prikhodko, Andrew Zhang, Mayra Blanco, Nhi Lang, Juan Piña-Crespo, Tomohiro Nakamura, Marisa Roberto, Stuart A. Lipton
This study shows that S-nitrosylation of CRTC1 impairs CREB-dependent gene expression in Alzheimer's disease models, leading to synaptic dysfunction and suggesting a therapeutic target.
Proceedings of the National Academy of Sciences · Feb 27, 2025Peer-reviewedNeuroscience