The Spliceosome Scaffold Component BCAS2 Promotes Pancreatic Cancer Progression through Weak 5 Splice Site Dependent Splicing Regulation
Ledong Wan, Mei Wang, Yuma Ishigami, Alexander J. Kral, Kuan-Ting Lin, Joseph R. Merrill, Scott K. Lyons, Adrian R. Krainer
This study identifies BCAS2 as a critical regulator of PDAC progression by promoting alternative splicing of weak 5' splice sites, specifically enhancing SOS1 exon 21 inclusion and RAC-signaling activation.
bioRxiv · Oct 7, 2026 · PreprintCancer Biology