Ledong Wan

This study identifies BCAS2 as a critical regulator of PDAC progression by promoting alternative splicing of weak 5' splice sites, specifically enhancing SOS1 exon 21 inclusion and RAC-signaling activation.

The paper identifies a MYC-USP39-SRSF1 regulatory axis in PDAC that stabilizes SRSF1 and promotes tumor progression, suggesting USP39 as a therapeutic target.

This study identifies an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer and shows that splice-switching ASOs targeting AURKA 5'UTR splicing disrupts this circuit, reducing cell viability and inducing apoptosis.

The paper identifies MED12-p63 interaction as a driver of basal identity in PDAC through genetic screens and biochemical analysis.