NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism
Qi Yang, Junsong Liu, Yuanyuan Wang, Rong Zhao, Hexiang Li, Yao Yao, C B Xu, Bo Kou, Meng Lei, Qian Zhao, Xin Chen, Honghui Li, Ruimin Zhao, Rongrong Cui, Meichen Wang, , Peng Hou
This study identifies an NFIC-driven endo-lysosomal pathway causing CaSR downregulation in SHPT and shows HCQ can reverse this process.
bioRxiv · May 9, 2026 · PreprintCell Biology