NFIC-mediated CaSR endocytosis defines a hyperactive TOMM20highCHGAhigh oxyphil cell state as a pathological driver of autonomous secondary hyperparathyroidism
Qi Yang, Junsong Liu, Yuanyuan Wang…·Peng Hou
This study identifies an NFIC-driven endo-lysosomal pathway causing CaSR downregulation in SHPT and shows HCQ can reverse this process.