PRE-INJURY MECHANORECEPTOR ABLATION REDUCES NOCICEPTOR-DRIVEN SPINAL CORD INJURY-INDUCED NEUROPATHIC PAIN
Christopher Sliwinski, Laura Heutehaus, Francisco José Taberner, Lisa Weiss, Vasileios Kampanis, Bahardokht Tolou-Dabbaghian, Xing Cheng, Melanie Motsch, Paul A. Heppenstall, Rohini Kuner, Steffen Franz, Stefan G. Lechner, Norbert Weidner, Radhika Puttagunta
This study investigates the role of mechanoreceptors and nociceptors in spinal cord injury-induced neuropathic pain, finding that early mechanoreceptor ablation reduces pain behavior, while nociceptor hyperexcitability and sprouting are key drivers of pain.
Pain · Dec 27, 2023Peer-reviewedNeuroscience