High glucose-induced ubiquitylation of G6PD leads to the injury of podocyte
Meng Wang, Ji Hu, Linling Yan, Yeping Yang, Min He, Shizhe Guo, Meng Wu, Qin Li, Wei Gong, Yang Yang, Diane E. Handy, Bin Lu, Chuanming Hao, Qinghua Wang, Yiming Li, , Zhaoyun Zhang
This study shows high glucose induces ubiquitylation of G6PD via VHL, leading to ROS accumulation and podocyte injury in diabetic kidney disease.
bioRxiv · Jun 20, 2018 · PreprintCell Biology