Meng Wang

Biallelic germline variants in the hematologic malignancy predisposition gene DDX41 cause retinal dystrophy through dysregulation of retinal homeostasis.

The paper identifies biallelic DDX41 variants in LCA/EOSRD patients and shows they disrupt retinal homeostasis through loss-of-function mechanisms in mouse models.

Engineered cell-like vesicles instruct keratocyte differentiation for corneal biofabrication and regeneration

The paper uses growth factor-loaded vesicles to direct keratocyte differentiation in 3D corneal constructs without repeated soluble growth factor supplementation.

BTK inhibition enhances immunovirotherapy in glioblastoma via tertiary lymphoid structure modulation

This study shows that BTK inhibition enhances oncolytic virotherapy in glioblastoma by promoting tertiary lymphoid structure formation and improving immune cell infiltration.

Monitoring Gene Expression in Retina with Synthetic Serum Markers

This study uses synthetic serum markers (RMAs) to monitor retinal gene expression and cell survival through blood tests, showing high sensitivity and non-destructiveness.

Intraperitoneal programming of tailored CAR macrophages via mRNA-LNP to boost cancer immunotherapy

This study develops an mRNA-LNP delivery system to program CAR-Ms in vivo, showing enhanced antitumor effects through immune activation and synergy with PD-1/L1 therapy.

Systematic assessment of the contribution of structural variants to inherited retinal diseases

This study identifies 16 pathogenic structural variants in 16 IRD families using whole-genome sequencing, finding SVs contribute 2.1% to unresolved IRD cases but less than SNVs and indels.

Reproducible abnormalities of functional gradient reliably predict clinical and cognitive symptoms in schizophrenia

The paper identifies reproducible functional gradient abnormalities in schizophrenia that correlate with clinical and cognitive symptom severity using resting-state fMRI data.

Nach is a novel ancestral subfamily of the CNC-bZIP transcription factors selected during evolution from the marine bacteria to human

The paper identifies a novel ancestral subfamily of CNC-bZIP transcription factors, Nach, tracing their evolutionary origin from marine bacteria to humans and showing distinct functional differences from Nrf1/2.

Loss of SDHB reprograms energy metabolisms and inhibits high fat diet induced metabolic syndromes

This study shows that SDHB deficiency reprograms energy metabolism and protects against high fat diet-induced obesity by restoring glucose and lipid metabolism.