Neural Crest-Derived Endocardial Cells Required for Heart Valve Development
Alexander F. Merriman, Mauro W. Costa, Angelo Pelonero, Yu Huang, Tomohiro Nishino, Feiya Li, Adrienne Lam, Abigail Brand, Victoria Yu, Yan Hu, Feng Gao, Irfan S. Kathiriya, Shafkat Anwar, Michael Bunker, Sanjeev S. Ranade, , Deepak Srivastava
The paper identifies a rare population of neural crest-derived endocardial cells essential for heart valve development in mice and humans, showing their role in valve morphogenesis through Pthlh signaling.
bioRxiv · Nov 4, 2026 · PreprintDevelopmental Biology